Others prefer evening injection, hoping to sleep through the initial adjustment window
Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023
Topical minoxidil Minoxidil remains the most evidence-based topical treatment for hair loss of almost any etiology
Plisson F, Hill TA, Mitchell JM, et al
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In their separate trials, retatrutides top dose produced an average weight loss of 28.3%, compared with 20.7% for Wegovy 7.2 mg in STEP UP