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Am J Physiol Endocrinol Metabol

Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

The two principal incretins , GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), act together with insulin and glucagon to regulate glucose homeostasis and energy balance [1]