HDAC inhibition by SX-275 restores expression of silenced leukemia-associated transcription factors Nur77 and NOR1 key pro-apoptotic proteins in AML
Side effects determine whether people actually complete treatment
Non-randomised studies were included as they primarily address pharmacokinetic, neuroimaging, and mechanistic endpoints, such as central nervous system bioavailability and glutathione redox status, which are often not adequately evaluated in the RCT studies
Future research should prioritize the refinement of GLP-1based therapies by addressing limitations such as elevated GLP-1 levels and receptor desensitization, while ensuring their safety and efficacy in older populations
Folate-rich foods include leafy greens, lentils, many green vegetables, and liver
doi: 10.1007/s00011-021-01495-6 60 LiuYGuW