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Although the CR group exhibited significantly lower lumbar spine and hip BMD compared to controls, there were no significant differences in serum CTX, bone-specific alkaline phosphatase (BSAP) levels, or trabecular microarchitecture parameters (e.g., erosion index, surface-to-volume ratio) between the groups

p = 0.004) [30]

Extreme restriction is unnecessary and often counterproductive, causing metabolic slowdown that persists beyond the protocol

Retatrutide is in Phase 3 clinical trials through Eli Lilly, and cagrilintide is in Phase 3 trials through Novo Nordisk (both as monotherapy and as part of CagriSema)

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