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Abbreviations AID: Activation-induced cytidine deaminase Akt: Protein Kinase B ALI: Acute lung injury AMD: Age-related macular degeneration AP-1: Activator protein-1 APC: Antigen presenting cell BCR: B cell receptor Breg: Regulatory B cell CFH: Complement factor H CVD: Cardiovascular disease DC: Dendritic cell DGE: German Nutrition Society ECM: Extracellular matrix EFSA: European Food Safety Authority eNOS: Endothelial nitric oxide synthase ERK1/2: Extracellular-signal regulated kinases 1/2 fMLP: N-formylmethionyl-leucyl-phenylalanine FOXO1: Forkhead box protein O1 G-CSF: Granulocyte-colony stimulating factor GM-CSF: Granulocytemacrophage colony stimulating factor GPR39: G protein-coupled receptor 39 GSK3: Glycogen synthase kinase 3 HCC: Hepatocellular carcinoma HDL-C: High-density lipoprotein cholesterol HIF-1: Hypoxia-inducible factor-1 HLA: Human leucocyte antigen HSC: Hematopoietic stem cell IFN: Interferon Ig: Immunoglobulin IL: Interleukin iNOS: Inducible nitric oxide synthase IRS: Insulin receptor substrates KIR: Killer cell immunoglobulin-like receptor LDL-C: Low-density lipoprotein cholesterol LPS: Lipopolysaccharide MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemotactic protein-1 mDC: Myeloid dendritic cell MDD: Major Depressive Disorder MHC: Major histocompatibility complex MLC: Mixed lymphocyte culture MMP: Matrix metalloproteinase MPO: Myeloperoxidase MT: Metallothionein mTORC1: Mammalian target of rapamycin complex 1 NET: Neutrophils release extracellular trap NF-B: Nuclear factor kappa-light-chain-enhancer of activated B-cells NIH: National Institutes of Health NK cells: Natural killer cell NLR: Neutrophil-to-lymphocyte ratio PAMP: Pathogen-associated molecular patterns PBMC: Peripheral blood mononuclear cell PD-1: Programmed Cell Death Protein 1 PD-L: Programmed Death-Ligand pDC: Plasmacytoid dendritic cell PHA: Phytohemagglutinin PI3 K: Phosphoinositide 3-kinase PIP 3 : Phosphatidylinositol-3,4,5-trisphosphat PKC: Protein kinase C PMN: Polymorphonuclear neutrophil PP2 A: Protein phosphatase 2 PPAR: Peroxisome proliferator-activated receptor PTEN: Phosphatase and tensin homolog PTP1B: Tyrosine phosphatase 1B ROS: Reactive oxygen species RPE: Retinal pigment epithelium S6 K: S6 kinase SNP: Single nucleotide polymorphism SOD: Superoxide dismutase TC: Total cholesterol TCR: T cell receptor TGF: Transforming growth factor TLR: Toll-like receptor TNF: Tumor necrosis factor TPEN: N , N , N , N -Tetrakis(2-pyridinylmethyl)-1,2-ethanediamine Tregs: Regulatory T cell VCAM-1: Vascular cell adhesion molecule-1 VEGF: Vascular endothelial growth factor WHO: World Health Organization XCI: X chromosome inactivation Xi: Inactive X chromosome ZAG: Zinc-2-glycoprotein ZD: Zinc deficiency ZnT: Zinc transporter References Jaul E, Barron J

They also measured the amount of thromboxane A2 (TXA2) produced by activated platelets in diabetic versus control subjects, finding that diabetic subjects produce more TXA2 than control subjects

Enhanced expression of AGEs/RAGE signaling occurs in patients with diabetes and impacts the development of diabetes-related metabolic complications (Table 3