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Abbreviations CCK: Cholecystokinin FFAR: Free fatty acid receptor FGF21: Fibroblast growth factor-21 GCGR: Glucagon receptor GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 MASLD: Metabolic dysfunction-associated steatotic liver disease SGLT: Sodiumglucose cotransporter SNAC: Sodium N-(8-[2-hydroxybenzoyl] amino) caprylate References Bailey CJ, Day C (2018) Treatment of type 2 diabetes: future approaches

Digestive health remains an important part of overall wellness while taking GLP-1 medications

However, side effects of GLP-1 RAs, particularly those affecting the gastrointestinal system, may limit their use in patients with IBD

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Tips to manage side effects Eat smaller meals and avoid very fatty or spicy foods to help reduce nausea

They will win on: * Tolerability * Long-term adherence * Manufacturing economics * Access Science is moving fast