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Epigenetic Interplay of Signal Transduction Regulation The connection between signal transduction defects and ASD pathology has opened up the treatment possibility of pharmacologically targeting these pathways, including PI3K/AKT/mTOR (mTOR), Wnt/-catenin (WNT), Notch, brain-derived neurotrophic factor (BDNF)-TrkB, sonic hedgehog, retinoic acid, bone morphogenetic protein (BMP), and MAPK/ERK pathways
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Vitamin B12 is an essential nutrient that humans need to ingest on a regular basis because it is a water soluble vitamin that cannot be stored in your body
Consequently, strategic inhibition of autophagy has been shown to restore antigen presentation and synergize with immunotherapy in preclinical NSCLC models (74)
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