GRAS status does not equal drug approval, but it does indicate that the regulatory body considered the compound safe for human consumption at the doses tested
A study in 650 elderly men and women reported that the risk of elevated plasma homocysteine levels was significantly higher in those with lower cognitive function scores (72)
The standard regimen involves: Loading doses without neurological involvement : 1 mg intramuscularly three times a week for 2 weeks [3] [8] Loading doses with neurological involvement : 1 mg intramuscularly on alternate days until no further improvement [3] [8] Maintenance therapy : 1 mg every 23 months for life in cases of pernicious anaemia or irreversible malabsorption (every 2 months if neurological involvement) [3] [8] This aggressive approach aims to prevent irreversible neurological damage, though recovery of established neuropathy may be incomplete, particularly if treatment is delayed
Patients on metformin, proton pump inhibitors, or H2 blockers have higher B12 deficiency risk and may benefit from supplementation
they are not for human consumption, medical, diagnostic, cosmetic, veterinary, or any other non-research application
Some people need a short course, while others with long-term deficiency may require regular injections as advised by a healthcare professional
