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residents to protect their own supply for Canadian citizens

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The most common side effects are gastrointestinal (think: constipation, diarrhea, or an upset stomach)

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That changed when the SURMOUNT-5 trial compared tirzepatide (the active ingredient in Zepbound) and semaglutide directly

These cerebral actions of GLP-1 are unlikely to reflect the actions of peripherally produced GLP-1 but are rather targets for GLP-1 produced in and released from projections of neurons of the nucleus of the solitary tract, which express the proglucagon gene and have a processing pattern like the L cells of the gut