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The adverse effects associated with imiquimod treatment are postinflammatory dyschromia, frequent erythema and edema, erosions, telangiectasia,110 superinfection, and reversible punctate keratopathy with reduced visual acuity in periocular lesions.117 Systemic effects include cytokine release syndrome (headache, gastrointestinal discomfort, fever, and general malaise)