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The safety data is reassuring copper peptides have shown excellent tolerability across all studies, with no serious adverse effects

Physiological experiments in human volunteers revealed different increments in insulin secretion after oral and intravenous glucose administration, which were subsequently attributed to the actions of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) [1]

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The nitrile forms a covalent imidate with the hydroxyl group of Ser630, which subsequently forms a hydrogen bond with the hydroxyl side group of Tyr547