For skin brightening specifically, oral or liposomal oral forms are the better-supported, lower-risk starting point
For the reporter assay, cells were transfected with a Gaussia luciferase (GLUC) plasmid containing either the human SIRT1 promoter (HRPM35661-PG02, Genecopoeia, USA) or the mouse HK2 promoter (MPRM42494-PG02, Genecopoeia) sequence, along with a Renilla luciferase plasmid
Briefly, the blood samples from indicated groups were kept for 30 min at room temperature, followed by centrifugation (3000 rpm/min) for 15 min at 4C
Clinical trials suggest it can lead to a weight reduction of 15-20% over a year, offering potentially better results than Ozempic
7.2/10 THOUGHTS
10+ years of experience in obesity care Treated 250+ patients with GLP-1 medications 13+ years of experience in obesity care Treated 280+ patients with GLP-1 medications 10+ years of experience in obesity care Treated 240+ patients with GLP-1 medications 8+ years of experience in obesity care Treated 250+ patients with GLP-1 medications THE SCIENCE How GLP-1 works with your body GLP-1 medications mimic a natural hormone that regulates appetite, digestion, and blood sugar helping your body lose weight more effectively Appetite Reduction Feel less hungry, more in control Slower Digestion Stay full for longer Blood sugar control Fewer spikes, fewer cravings Metabolic Support Improves how your body uses energy Mean weight loss, injection 2.4mg at 68 wk STEP 1 NEJM 2021 Mean weight loss, pill 25mg at 64 wk OASIS 4 NEJM 2025 Weight loss with investigational 7.2mg dose STEP UP ADA 2025 Reduced risk of heart attack, stroke, CV death SELECT NEJM 2023 SAFETY & SUPPORT Start with care
