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An increase in fasting blood glucose is also observed

PDI has two active sites, both of which are characterized by the presence of a CGHC motif, which either forms a disulphide for the enzyme to become active as an oxidase, or a dithiol for the enzyme to act as an isomerase

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Most of plant GPXs prefer to use thioredoxin (TRX) instead of glutathione as a reducing agent, and it is thought that the GPXs may represent a link between the glutathione- and the thioredoxin-based system