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Fatigue in this context is generally considered a physiological response to the drug's mechanism rather than a sign of serious harm, though it should always be monitored carefully

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Bolanos CA, Barrot M, Berton O, Wallace-Black D, Nestler EJ (2003)

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The timing connection: understanding when your appetite will be lowest (peak drug levels, days 1 to 3) lets you plan your highest-protein meals for the days when you have relatively more appetite (days 5 to 7)

Inconsistency: You won't see the full benefits of this pairing after a single dose