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The decision to use GLP-1 receptor agonists should be based on their licensed indications (diabetes or obesity management) rather than cholesterol lowering alone, with lipid improvements considered a beneficial additional effect within a comprehensive cardiovascular risk reduction strategy

5.4% WL with 14 mg oral semaglutide after 68 weeks at the PIONEER PLUS trial (Fig

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We like to call this the Hardware and Software Approach

(2023, New England Journal of Medicine) Obesity Trial Study Design : Randomized, double-blind, placebo-controlled Phase 2 trial in adults with obesity or overweight

27(4):921 to 930., Review article by the founder of the field