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Synaptic and extrasynaptic NMDAR activation exert opposing neural protective and neurotoxic effects, respectively, and these processes involve a variety of corresponding neuroprotective and apoptotic pathways ( Metabotropic Glutamate Receptors Glutamate can also activate a type of G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs)

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Although the underlying mechanisms between vitamin D and ASD are not clearly clarified, there is some biological evidence showing the relationship between them [96]

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