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Cualquier uso debe realizarse bajo la supervisin de un profesional de la salud cualificado

Recent conceptual frameworks propose that metabolic stress and impaired incretin signaling may amplify interleukin (IL) 23/17driven immune responses at the enthesis and synovium, thereby facilitating the transition from PsO to psoriatic arthritis (PsA) in genetically or immunologically predisposed individuals (9)

The FDA granted the application a Priority Review designation, and the drug also received a Commissioner National Priority Voucher, which could further accelerate the review process

some respond strongly at lower doses, while others report minimal benefit

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Table 1 Magnitude of the literature retrievable on PubMed at two indicative time points