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Advanced glycation end products (AGEs) that impair dopaminergic signaling

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These neurons co-express Dbh and Slc6a2 (the norepinephrine transporter), and upregulate Pdyn upon semaglutide treatment, suggesting increased production of multiple immunomodulatory factors

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Finally, MITF nuclear localization was expressed as the percentage of nuclear signal relative to total cellular signal (value for immunoreactivity in the nucleus/value for immunoreactivity in the whole cell 100), allowing comparison of nuclear enrichment across ECM conditions

Like NPY, MCH exerts pleiotropic effects on locomotor activity, sensory processing, anxiety, aggression, and learning