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The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)
The metabolic syndrome amplifies AGE-RAGE signaling, with methylglyoxal-derived AGEs being particularly prominent (78)
This medicine is known to help with weight management and blood sugar control
How common are the risks of severe GI side effects when taking GLP-1 medications