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The cumulative fractional labeling from palmitate and glucose in DKO cell histone acetylation matches that by WT and ACSS2 KO cells, while ACLY KO cells have much lower cumulative labeling from these two sources, consistent with unlabeled acetate feeding the acetyl-CoA pool only in those cells (Supplemental Figure 5D)

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Limited Clinical Safety Data : The human safety profile remains unclear because the evidence is primarily based on animal and laboratory studies rather than large-scale clinical trials