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It works in a different way than most other treatments

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All other efforts ( i + 3 , i + 4 , Aib, etc.), including analogs with staples oriented at the hydrophobic interface, did not provide peptides with comparable activity

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Indeed, proteasome-dependent proteolysis of carbonylated proteins that were extensively present in late log phase epimastigote cultures was suggested to signal metacyclogenesis (Cardoso et al., Nucleotides Synthesis and DNA Replication Cellular DNA synthesis and proliferation, as well as DNA repair mechanisms depend on the production of a balanced supply of deoxyribonucleotides (dNTPs)