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Cardiovascular Outcomes in Patients Treated with Semaglutide for Type 2 Diabetes

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In addition, deletion of the GSH1 geneencoding glutamylcysteine synthetase (GCS), the enzyme catalysing the first step in glutathione synthesiswas shown to suppress an Ero1 conditional mutant, again indicating that GSH provides an additional load on Ero1 activity (Frand & Kaiser, 1998)

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Because of this, Nmnat has also been seen as a viable target for cancer therapies