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Neurodegenerative diseases are characterized by progressive neuron losses in specific brain regions that impact cognitive, sensory, and motor functioning

Proteins with an N-terminal his tag (GSTs A1-1, A2-2, A3-3, P1-1, and S1-1) were purified as follows

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Table 1 : Fictitious Example (If a patient has an estriol of 2, an estrone of 2, a 16 a-OHE1 of 2, and an estradiol of 2, then the Total Estrogen Effect (TEE) would be 48 based on their relative binding affinities) **Although 16a-OHE1 is a Phase I metabolite, it is included in the calculation due to its ability to contribute to estrogen dominance

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