Roels H, Djubgang J, Buchet JP, Bernard A, Lauwerys R
doi:10.1016/j.ebiom.2025.105836 Compliance Statement This product is intended for laboratory research use only and is not approved for human or veterinary use.
In some people, microbial imbalance plays a major role
Drug combination studies showed that NBDHEX is significantly active on cisplatin-resistant human osteosarcoma cells 77
This work was funded by the National Heart, Lung and Blood Institute (R01HL095388 to AS and MEL), National Center for Advancing Translational Science (UL1 TR000157 to AS and MEL), National Science Foundation (Integrative Graduate Education and Research Traineeship to JDC and JEZ), British Columbia Lung Association, Canadian Institute for Health Research, Parker B Francis Foundation (Senior Fellowship to TLH) and the Dutch Asthma Foundation and European Respiratory Society (International Research Fellowship to CAB)
Multiple dose levels (1, 4, 8, 12 mg) were tested in Phase 2, with the Phase 3 dose selection to be refined based on efficacy-tolerability balance