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33,34 Bone-derived signals, such as osteocalcin (a non-collagenous protein secreted by osteoblasts) and sclerostin (a glycoprotein produced by osteocytes), maintain a bidirectional dialogue with energy metabolism and may influence systemic homeostasis, producing trans-systemic effects during growth

Example 1 For reference, embodiments of contemplated dosages and/or dosage regimens are set out in Example 1 below

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e-Pub 1981

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