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However, severe or persistent tiredness beyond 8 weeks may indicate an individual response requiring dose adjustment or medication switch

However, they were closely linked to many processes associated with inflammation, including cell proliferation (NES, NME1, PRAME), endocytosis (NME1, RAB1A, DNM2, TRIP10), protein folding (VBP1, CRTAP, PDIA5), cell adhesion (RAB1A, DNM2, ICAM1), proteolysis (LONP1, PRSS23) and transcription (TPR, PRPF6, HIST1H1B, HIST1H1E, PRAME, DNME2)