Further, a recent study showed that cardiomyocytes produce diffusible redox mediators (e.g., H 2 O 2 ) that promote PCD in amastigotes and control intracellular proliferation of parasite (Estrada et al., 2018)
Another promising target is the cytochrome bc1 complex, with inhibitors disrupting mitochondrial function in Leishmania species, leading to parasite death (Saldivia et al., 2024)
One dose a week: CagriSema in the trials is once-weekly, not daily
The GIP receptor activation may contribute to the overall metabolic benefits
Hormone balancing is not an evidence-based description The available studies do not establish that DSIP normalises cortisol, increases growth hormone or restores a general hormonal balance in humans
High endothelial venules (HEVs) in immunity, inflammation and cancer