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Comment: Many commenters disagreed with the proposal to require hospitals to encode the name of the CEO, president, or senior hospital official designated to oversee the encoding of true, accurate, and complete data in the MRF because it would be unnecessarily burdensome to the hospital executive, hinder their ability to fulfill their primary role of focusing on strategic vision and overall governance, or introduce delays without improving accuracy

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They are metabolised via the thiopurine S-methyltransferase (TPMT) enzyme, and polymorphisms in the gene encoding this enzyme can lead to variable enzyme activity and potential toxicity

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