18 The prescribing information for oral semaglutide notes that the most common side effects with use include nausea, abdominal pain, diarrhea, decreased appetite, vomiting, and constipation
It is a hormone produced primarily in the small intestine (specifically in the L cells which line this part of your digestive tract), though some neurons in your brain also produce it
Sisley and colleagues used mouse genetics to inactivate the Glp1r in the mouse brain, demonstrating that the acute anorectic and chronic weight lossinducing pharmacological actions of GLP-1RA required GLP-1R expression in the central nervous system (10)
Despite declining sharply among lookalike respondents, emotional well-being improved among current GLP-1 users this month
One paper suggested that GLP-1s may improve some gut health symptoms (such as abdominal pain) but worsen others (such as regularity and constipation)
One possible way to minimize the side-effects of the single drugs is to combine them to achieve synergistic effects, as reported recently with a combination of a DPP-IV inhibition, SSTR5 antagonism and GPR40 and TGR5 agonism, capable to raise circulatory active GLP-1(7-36) NH2 levels to more than 300-400 pM in mice (240)
