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Journal of the ASEAN Federation of Endocrine Societies , 37 (2), 65-72

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Furthermore, mice treated with SRT1720, a potent, selective synthetic activator of SIRT1, were resistant to diet-induced obesity due to enhanced oxidative metabolism in skeletal muscle, liver, and brown adipose tissue, indicating the positive metabolic consequences of specific SIRT1 activation (227)

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By incorporating specific evaluation metrics, such as drug-likeness and synthetic accessibility, the generated linkers show favorable theoretical drug-like properties and synthetic accessibility, though their actual efficacy, safety, and stability require further experimental evaluation