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The activation and subsequent engagement of the insulin receptor (IR) and its downstream mediators, IRS-1 and IRS-2, remain critical for regulating insulin signaling (Mary et al., 2002)

In some embodiments, an otic composition or formulation disclosed herein comprises less than about 25 ppm of each of C1-C4 alcohols or C1-C4 glycols

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Mechanisms that regulate the activities of TET proteins

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