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Genetic research has identified markers associated with varying responses to GLP-1 therapy, including variants in the GLP1R gene, GIPR gene, and metabolic regulators like FTO and MC4R

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The consequences of this difference have been recognised in the investigation of the toxic mechanisms associated with gout, where the concentrations of UA that induce peripheral microcrystallisation and its related inflammatory reaction are not easily reached in rodents

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Results showed that PPA-treated animals spent significantly less time interacting with a conspecific animal than control animals ( p 0.75), with high sensitivity and specificity