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Clinical Evidence 2026 Update: Phase 3 TRIUMPH Data In December 2025, Eli Lilly reported the first successful Phase 3 readout for retatrutide (LY3437943) from the TRIUMPH-4 trial

1,6 Despite normal secretion of GLP-1 and GIP, the incretin effect is reduced or absent in people with type 2 diabetes, with the insulin-stimulating effect of GIP being more impaired when compared to GLP-1

Not intended to diagnose, treat, cure, or prevent disease

She told Vogue that she gets her protein fill from beans

The sections below walk through each step in detail, starting with what makes retatrutide fundamentally different from other weight loss peptides on the market

Each person responds differently to medications, and the degree of weight loss achieved with treatment can vary based on personal factors, said Priya Jaisinghani, MD, a clinical assistant professor specializing in obesity medicine at the NYU Grossman School of Medicine