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doi: 10.1289/ehp.845537
These side effects are typically minor and short-lived
Everything needs to be in balance.[ref][ref] Prostate cancer risk is increased with 4-HOE1(E2) metabolites also.[ref] In general, the estrogen metabolites that start with 2 are good, and the ones that start with 4 or 16 need to be limited or at least eliminated quickly from the body.[ref] Here is a diagram of how these metabolites go together: As you can see, upregulating the CYP1A1 enzyme is going to increase the 2-OHE1 path
Abnormal concentrations of organic acids may result from micronutrient insufficiencies, toxin exposure, neuroendocrine activity, enzyme deficiencies, or the overgrowth of certain bacteria or fungi in the intestines
Long-term use of certain medications such as metformin and proton pump inhibitors (PPIs) also increases the risk of B12 deficiency
Is Homocysteine Bad
