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Even within the current landscape, some people respond better to one medication over another based on their individual side effect profile

The glucoregulatory actions of GLP-1RAs are well known and include glucose-dependent stimulation of insulin secretion and inhibition of glucagon release, resulting in a marked reduction in HbA 1c in people with type 2 diabetes

Kato R, Matsui-Yuasa I, Azuma H, Kojima-Yuasa A

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Magnsdttir, S., Ravcheev, D., de Crcy-Lagard, V

The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice