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Polyphenols are a large family of natural compounds characterized by the presence of phenolic hydroxyls (with aromatic rings), which include four main classes: phenolic acids, flavonoids, stilbenes, and lignans [58]

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Increasing NAD + by supplementing NR can remarkably normalize DNA damage, p-Tau, synaptic transmission and neuroinflammation, improve the ability of motor function, memory and learning and increase the activity of SIRT3 in the brain