While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician
In HFD-induced rat models of insulin resistance and hepatic steatosis, FBA showed comparable therapeutic efficacy to NaBu, with significantly greater potency in reducing pro-inflammatory parameters, lipid accumulation, and HMGB1 transcription [103]
The 4 mg maintenance dose produced 17.1% average weight loss across the full trial population, but lighter individuals within that group often experienced responses closer to 20% or higher
Oral glutathione has significantly lower bioavailability because it is partially broken down during digestion
Finally, the review notes that a couple of clinical studies on TB4 for wound healing both resulted in the peptide accelerating the healing process.21 March 2024 study Interestingly, in a 2024 study, researchers found that TB-500 (Ac-LKKTETQ) didnt increase wound-healing activity, but one of its metabolites Ac-LKKTE did
It also has a specific FDA-approved indication for reducing excess abdominal fat in HIV-infected adults with lipodystrophy
