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The study reveals that BPC-157-induced GHR expression increases sensitivity to growth hormone signaling: adding growth hormone to BPC-157-treated fibroblasts dose- and time-dependently increased cell proliferation (MTT assay and PCNA) and activated the downstream Janus kinase 2 (JAK2) pathway

KEAP1-mediated ubiquitination can target NRF2 for protein degradation

S1a) 31,32

Simulations were conducted in the full rotation mode where the ligand is flexible, but the receptor is rigid

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