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This includes phentermine and novel GLP-1 medicines, including liraglutide (Ozempic) and tripeptide (Munjaro)

Following peripheral administration, exenatide has been shown to suppress food intake via vagal-dependent and vagal-independent pathways that result in the direct activation of GLP-1R in the central nervous system

Retatrutides top-line Phase 2 data showed higher mean body-weight reduction than tirzepatides landmark trial results

However, semaglutide has FDA-approved uses under specific brand names and indications, while retatrutide remains investigational

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Yes, as with other incretin-based therapies, nausea, diarrhea, and reduced appetite are among the most commonly reported side effects, especially during dose escalation