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On average, the head-to-head trial favored tirzepatide, but while tirzepatide may potentially be more effective, individual results vary and some people do very well on semaglutide

These can include significant weight loss, better body composition, improved mobility, higher energy levels, and greater confidence

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Providers are increasingly seeing side effects such as: Nausea, vomiting, and delayed gastric emptying Fatigue and muscle loss during rapid weight loss Micronutrient depletion from reduced food intake Emotional dysregulation related to appetite and blood sugar swings Plateaus or weight regain after discontinuation Some patients also feel disconnected from their hunger cues or experience anxiety about long-term dependency on injections

The 12mg dose at 120 units (1.20mL) is borderline and can be handled with a single draw using a syringe rated for at least 1.2mL, or a clean 60/60 unit split using two standard syringes