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The next important group of H 2 S prodrugs, some of which entered the clinical phase, includes H 2 S-releasing modifications of many clinically used drugs with the well-known ATB-346 which is a H 2 S-releasing derivative of naproxen [170,171] (Figure 12)

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Kang, Seung-Gul, et al

However, unlike endogenous GLP-1, which breaks down rapidly in the body, Sema has been chemically modified to be long-acting and resistant to enzymatic degradation