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In addition, the cases of oral hyperpigmentation reported to date do not appear to be drug dose-dependent (Table 2)

For example, researchers have used the gene-editing tool CRISPR to produce an exhaustive panel of mutations in the breast cancer gene BRCA1 and to study how these mutations affect gene function 5

Of significance is the fact that the thiazolidinedione (TZD) class of drugs used to treat the hyperglycemia of type 2 diabetes (see the next section) activate PPAR which in turn increases the level of activity of PGC-1

A notable rise in global prevalence of diabetes and obesity has accelerated product adoption in both developed and emerging markets

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Czonkowska, A., Rodo, M., Wierzchowska-Ciok, A., Smolinski, L