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The main effect of Creatine is the reconversion (resynthesis) of burned energy (ADP) into available energy (ATP)

A decline in estrogen levels after menopause contributes to an increase in heart attack and stroke risk

In addition, human umbilical vein endothelial cells (HUVEC) also exhibited an upregulation of eNOS and enhanced Akt phosphorylation, which plays an important role in vasodilation

doi: 10.1038/s41581-021-00394-7 176 ZhouMZhangXWenXWuTWangWYangMet al

Even with partial breastfeeding, the same considerations apply: limited safety data, potential indirect effects on milk supply, and the availability of safer alternatives if medication is medically necessary