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Studies on bariatric surgery patients show anxiety scores decline significantly following substantial weight reduction, suggesting that the mechanical act of losing weight carries independent mental health benefits beyond any direct drug effect

While the relevance to humans remains unclear, regulatory agencies maintain this precaution as a safety measure

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In rats, exogenous brain-derived neurotrophic factor (BDNF) increased myoelectric activity and peristalsis in the gastrointestinal tract and colon ( Conclusion There has been extensive research into the effects of diverse classes of medications targeting different pathophysiological mechanisms including defective contraction or coordination of the stomach manifesting with symptoms and objective retardation of gastric emptying