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Importantly, these medications carry a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and are contraindicated in patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

503A facilities will be required to cease compounding immediately, while 503B outsourcing facilities will have a 60-day wind down period

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10.1155/2018/9150807 142 ZhengY.BaiL.ZhouY.TongR.ZengM.LiX.et al (2019)

Szener ZC, Cevhertas L, Nadeau K, Akdis M, Akdis CA

100443.2500) in a Mars 5 Xpress microwave digestion system (CEM, USA)