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Women in perimenopause: Hormones are already fluctuating, so changes in weight and metabolism can influence how symptoms show up

Clinically, retatrutide has been demonstrated to decrease visceral fat mass without sacrificing lean muscle, which is crucial for metabolic health and mitigating obesity-related risks

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Collectively, these findings position Orforglipron as a tool for evaluating integrated appetite-regulation and metabolic-signaling networks across multiple organ systems in laboratory settings