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Trends in utilization of glucose- and weight-lowering medications after tirzepatide approval in the United States: a population-based cohort study

New England Journal of Medicine , 391(25), 2347-2357

SCALE Obesity Trial

Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins

Local rashes most often come from three mechanisms: An immune response to the medication itself, sending histamine to the injection area Sensitivity to an inactive ingredient like a preservative or buffer in the formulation Mechanical trauma from the needle or a fast injection technique The immune explanation is straightforward: a neighborhood-level alarm that sends histamine and inflammatory signals, producing redness and itch

Except your dose was supposed to increase to 4mg at week 5, which means 80 units from the same vial