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Key protocol components, including eligibility criteria, treatment strategies, assignment procedures, follow-up, outcome definitions, causal contrast, identifying assumptions and the data analysis plan, were translated into operational definitions using validated claims-based algorithms and observational analogs of key study design choices

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Today, targeted gene tests make it possible to diagnose exactly where the methylation cycle is interrupted and thus enable specific therapy with the corresponding nutrients

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doi: 10.1016/S1474-4422(20)30231-3 [DOI] [PMC free article] [PubMed] [Google Scholar] 11