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More importantly for muscle-focused applications, the proportion of lean mass loss to total weight loss was similar to or better than other obesity treatments, with Retatrutide demonstrating significant improvements in total body fat mass reduction compared to both placebo and dulaglutide (a single-receptor GLP-1 agonist)
doi: 10.1203/00006450-200211000-00018 37
Further investigations are needed to elucidate the molecular mechanisms underlying IGF- 1R-mediated endothelial dysfunction, including oxidative stress [76,77,78], inflammation [30], pathways involved in cellular senescence [17], and metabolic alterations [79, 84, 85]
Potential Benefits in Type 2 Diabetes Though most research focuses on type 1 diabetes (where C-peptide is absent), some studies in type 2 diabetes also suggest that higher physiological C-peptide levels correlate with better kidney outcomes, hinting at protective roles even when endogenous production is present
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