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In a rat model of chronic pneumoconiosis induced by intratracheal injection of quartz powder, catalpol promotes mitochondrial biogenesis through the peroxisome proliferator-activated receptor- coactivator-1 alpha (PGC-1)/nuclear respiratory factor 1 (NRF1) and Transcription Factor A (TFAM) pathways, enhancing mitochondrial function in skeletal muscle, reducing muscle atrophy, and improving exercise capacity (Yu et al., 2022